KARLIK, STEPHEN J.,史帝夫Ｊ 卡利,PLEISS, MICHAEL A.,迈可Ａ 普莱斯,邁可Ａ 普萊斯,KONRADI, ANDREI W.,安德烈Ｗ 康莱迪,安德烈Ｗ 康萊迪,GRANT, FRANCINE S.,法兰西Ｓ 格兰,法蘭西Ｓ 格蘭,SEMKO, CHRISTOPHER M.,克里斯多佛Ｍ 山可,DRESSEN, DARREN,史帝夫J 卡利,迈可A 普莱斯,邁可A 普萊斯,安德烈W 康莱迪,安德烈W 康萊迪,法兰西S 格兰,法蘭西S 格蘭,克里斯多佛M 山可
申请号：
TW093101747
公开号：
TWI428141B
申请日:
2004.01.27
申请国别(地区):
TW
年份:
2014
代理人:
摘要：
The application provides for methods and compositions for inhibiting demyelination, promoting remyelination and/or treating paralysis in a subject in need thereof. Preferably, such compositions include immunoglobulins (e.g., antibodies, antibody fragments, and recombinantly produced antibodies or fragments), polypeptides (e.g., soluble forms of the ligand proteins for integrins) and small molecules, which when administered in an effective amount inhibits demyelination and/or promotes remyelination in a patient. The compositions and methods described herein can also utilize other anti-inflammatory agents used to palliate conditions and diseases associated with demyelination.本申請案係提供在有需要之病患中抑制脫髓鞘作用，促進髓鞘再形成及/或治療麻痺之方法與組合物。此種組合物較佳係包含免疫球蛋白(例如抗體、抗體片段及以重組方式產生之抗體或片段)、多肽(例如對整合素之配位體蛋白質之可溶形式)及小分子，當其以有效量投予時，係在病患中抑制脫髓鞘作用及/或促進髓鞘再形成。本文中所述之組合物與方法亦可利用其他用以舒減與脫髓鞘作用有關聯之症狀與疾病之消炎劑。
