The present invention relates to novel antibodies and fragments thereof that binds cannabinoid 1 (CB1) receptor. The antibodies and fragments thereof as disclosed herein include humanized antibodies that bind CB1 receptor. The invention also includes uses of the antibodies for treating a disease or disorder responsive to antagonism or agonism of the CB1 receptor.本發明係關於結合大麻素1(CB1)受體之新穎抗體及其片段。本文中揭示之抗體及其片段包括結合CB1受體之人類化抗體。本發明亦包括該等抗體用於治療對CB1受體之拮抗或促效作用有反應之疾病或病症之用途。