DNA damage repair inhibitors for treatment of cancer

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专利权人:

发明人:

申请号：

EP10178515.2

公开号：

EP2305221B1

申请日:

2004.11.30

申请国别(地区):

EP

年份:

2015

代理人:

摘要：

The present invention relates to the recognition that inhibition of the base excision repair pathway is selectively lethal in cells which are deficient in HR dependent DNA DSB repair. Methods and means relating to the treatment of cancers which are deficient in HR dependent DNA DSB repair using inhibitors which target base excision repair components, such as PARP, is provided herein.

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