Alan Ashworth,Stephen Jackson,Niall Martin,Graeme Smith,Mark O'Connor,Mark OConnor
申请号：
US11245735
公开号：
US08143241B2
申请日:
2005.10.06
申请国别(地区):
US
年份:
2012
代理人:
摘要：
The present invention relates to the recognition that inhibition of the base excision repair pathway is selectively lethal in cells which are deficient in HR dependent DNA DSB repair. Methods and means relating to the treatment of cancers which are deficient in HR dependent DNA DSB repair using inhibitors which target base excision repair components, such as PARP, is provided herein.
