The Institute of Cancer Research;KuDOS Pharmaceuticals Limited
发明人:
Jackson, Stephen Philip,Martin, Niall Morrison Barr,Smith, Graeme Cameron Murray,Ashworth, Alan
申请号：
AU2010202197
公开号：
AU2010202197B2
申请日:
2010.05.28
申请国别(地区):
AU
年份:
2013
代理人:
摘要：
#$%^&*AU2010202197B220130523.pdf#####ABSTRACT DNA Damage Repair Inhibitors for Treatment of Cancer The present invention relates to the recognition that inhibition of the base excision repair pathway is selectively lethal in cells which are deficient in HR dependent DNA DSB repair. Methods and means relating to the treatment of cancers which are deficient in HR dependent DNA DSB repair using inhibitors which target base excision repair components, such as PARP, is provided herein.
