The present invention provides compound of formula I: or its pharmaceutically acceptable salt, with and combinations thereof and application method, it inhibits the activity of Janus kinases (JAK) and can treat with JAK activity related disease, including such as inflammatory conditions, autoimmune disorder, cancer and other diseases with what.本發明提供式I化合物：或其藥學上可接受的鹽，以及其組合物和使用方法，其抑制Janus激酶(JAK)的活性且可用於治療與JAK活性有關的疾病，包括例如炎性病症、自體免疫病症、癌症以及其他疾病。
