The invention relates to compounds of formula (I): as described herein, pharmaceutical preparations comprising such compounds, uses and methods of use for such compounds in the treatment of a disorder or a disease mediated by the activity of MDM2 and/or MDM4, and combinations comprising such compounds.本發明係關於如本文中所述之式(I)化合物:包含該等化合物之醫藥製劑;該等化合物用於治療由MDM2及/或MDM4之活性所介導之病症或疾病的用途及使用方法;及包含該等化合物之組合。