RASNETSOV LEV DAVIDOVICH,SHVARTSMAN IAKOV YUDELEVICH,SUVOROVA OLGA NIKOLAEVNA
申请号：
IN2304/DELNP/2013
公开号：
IN2013DN02304A
申请日:
2013.03.14
申请国别(地区):
IN
年份:
2016
代理人:
摘要：
The invention relates to the pharmaceutical industry and to medicine, specifically to novel hydrated amino-acid derivatives of fullerene Cgo of general formula C6o(H)3{NH(CH2)nCOOH}3 xH20, where C60 - fullerene, n = 5,6,7, x = 8 -10, and also to a method for producing said derivatives, and to the production of pharmaceutical compositions on the basis thereof. Hydrated N- fullerene amino acids are formed in the interaction of fullerene with 15 times the molar excess of anhydrous potassium salts of amino acids in a medium of organic aromatic solvent with slow addition to the resultant suspension of an interphase catalyst and with mixing and heating to a temperature not exceeding 60�C until the solution is completely decolorized and a solid residue formed, after which the latter is separated out, and then 0.8 M of aqueous solutions of potassium salts of fullerene amino-acid derivatives is treated with a solution of organic or mineral acids, followed by centrifugation, rinsing and drying of the residue. A pharmaceutical composition which exhibits activity against the herpes virus, flu viruses of various origin and HIV, and also anti-tumor and antipsoriatic activity, comprising, as active substance, an effective quantity of hydrated Nfullerene amino acids.
