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HYDRATED N-FULLERENE AMINO ACIDS, METHOD FOR PRODUCING THE LATTER,AND PHARMACEUTICAL COMPOSITIONS ON THE BASIS THEREOF
专利权人:
RASNETSOV LEV DAVIDOVICH
发明人:
SHVARTSMAN LAKOV YUDELEVICH,RASNETSOV LEV DAVIDOVICH,SUVOROVA OLGA NIKOLAEVNA
申请号:
ZA201303448
公开号:
ZA201303448B
申请日:
2013.05.13
申请国别(地区):
ZA
年份:
2014
代理人:
摘要:
The invention relates to the pharmaceutical industry and to medicine, specifically to novel hydrated amino-acid derivatives of fullerene C 60 of general formula C 60 (H) 3 {NH(CH 2 ) n COOH} 3 ·xH 2 O, where C 60 - fullerene, n = 5, 6, 7, x = 8 - 10, and also to a method for producing said derivatives, and to the production of pharmaceutical compositions on the basis thereof. Hydrated N-fullerene amino acids are formed in the interaction of fullerene with 15 times the molar excess of anhydrous potassium salts of amino acids in a medium of organic aromatic solvent with slow addition to the resultant suspension of an interphase catalyst and with mixing and heating to a temperature not exceeding 60°C until the solution is completely decolorized and a solid residue formed, after which the latter is separated out, and then 0.8 M of aqueous solutions of potassium salts of fullerene amino-acid derivatives is treated with a solution of organic or mineral acids, followed by centrifugation, rinsing and drying of the residue. A pharmaceutical composition which exhibits activity against the herpes virus, flu viruses of various origin and HIV, and also anti-tumor and anti-psoriatic activity, comprising, as active substance, an effective quantity of hydrated N-fullerene amino acids.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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