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アンブロキソール含有製剤粒子
专利权人:
大正製薬株式会社
发明人:
浜下 智宏
申请号:
JP2011100277
公开号:
JP6084355B2
申请日:
2011.04.28
申请国别(地区):
JP
年份:
2017
代理人:
摘要:
PROBLEM TO BE SOLVED: To provide preparation particles constituting an ambroxol-blended sustained-release preparation taken as a granule agent or a dispersing agent as it is, formed as a capsule preparation by being encapsulated into a gelatin hard capsule, having a suitable size preventing enlargement of the preparations when being mixed with another excipient and subjected to compression molding to form a tablet, not requiring considerable time in the production thereof, delaying elution of ambroxol or a salt thereof when film coating is applied thereto, and retaining a medicinal effect of ambroxol over long hours from just after administration by being combined with immediate release ambroxol-containing particles, for example, preparation particles to which film coating is not applied.SOLUTION: The preparation particle does not include nuclear particles made of only an excipient, includes ambroxol or a salt thereof and the excipient, and has a mean particle diameter of 400-1,000 μm, and a geometric standard deviation of particle size distribution of ≤1.5.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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