Ross Strand;Xiaoli Wang;Maurice Joseph Prendergast
发明人:
Ross Strand,Maurice Joseph Prendergast,Xiaoli Wang
申请号：
US12266937
公开号：
US08906347B2
申请日:
2008.11.07
申请国别(地区):
US
年份:
2014
代理人:
摘要：
The present invention relates to an aqueous oral composition comprising:a) from 0.2% to 3% divalent metal ions comprising: i. from 0.1% to 1.5% of zinc ions；ii. from 0.1% to 2% of tin (II) ions； andb) a source of fluoride ions；c) a silica dental abrasive；d) one or more chelants having a MW of less than 1000 and capable of forming water-soluble complexes with the zinc ions, wherein the chelants comprise less than 0.2% linear polyphosphates having a chain length of four or more；e) an orally acceptable carrier comprising at least 20% total water；wherein the pH of the composition is from 5 to 6.5, the molar ratio of the chelants to the divalent metal ions is at least 0.70:1 and at least 80% by weight of the total zinc ions are solubilised within the composition.The composition of the invention has been found to give improved antimicrobial activity from the zinc/stannous combination without significant taste, staining or stability problems, compared to compositions having lower levels of chelants.
