The present invention includes solid compositions of triglycerides with one or more fatty acids, such as triheptanoin and glycerol phenylbutyrate, and therapeutic use thereof. The solid compositions can be prepared by spray-drying or other processes.本發明包括與一或多種脂肪酸形成之三酸甘油酯,諸如三庚酸甘油酯及苯丁酸甘油酯之固體組合物及其治療用途。該等固體組合物可藉由噴霧乾燥或其他方法來製備。