Inhibitors of Tryptophan Dioxygenases (IDO1 and TDO) And Their Use In Therapy

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专利权人:

发明人:

Brian Desmond Palmer,Lai-Ming Ching

申请号：

US15755750

公开号：

US20180244692A1

申请日:

2016.08.25

申请国别(地区):

US

年份:

2018

代理人:

摘要：

Pharmaceutical compositions comprising 3-aminoisoxazolopyridine compounds of the Formula I having IDO1 and/or TDO inhibitory activity are described, where W is CR1, N or N-oxide X is CR2, N or N-oxide Y is CR3, N or N-oxide Z is CR4, N or N-oxide and at least one of W, X, Y, and Z is N or N-oxide and R9 and R10 are as defined. Also described are methods of using such compounds in the treatment of various conditions, such as cancer.

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