AUCKLAND UNISERVICES LIMITED;Brian Desmond Palmer;Lai Ming Ching;Swarnalatha Akuratiya Gamage
发明人:
Brian Desmond Palmer,Lai Ming Ching,Swarnalatha Akuratiya Gamage
申请号：
US15503210
公开号：
US20170224701A1
申请日:
2015.08.12
申请国别(地区):
US
年份:
2017
代理人:
摘要：
Pharmaceutical compositions comprising 3-aminoisoxazolopyridine compounds of the Formula I having IDO1 and/or TDO inhibitory activity are described, where W is CR1, N or N-oxide； X is CR2, N or N-oxide； Y is CR3, N or N-oxide； Z is CR4, N or N-oxide； and at least one of W, X, Y, and Z is N or N-oxide； and R9 and R10 are as defined. Also described are methods of using such compounds in the treatment of various conditions, such as cancer.
