Ultrasound signal processing device including: transmitter causing transmission array composed of all or some transducer elements of ultrasound probe to transmit ultrasound; reception aperture setter designating reception array having center position corresponding to center position of transmission array; transmission time calculator calculating, for each of measurement points arranged within area of reach of ultrasound, transmission time from transmission of ultrasound until arrival of ultrasound at measurement point; reception time calculator calculating reception time from reflection of ultrasound at measurement point until arrival of ultrasound at reception transducer element; delay amount calculator calculating total propagation time being sum of transmission time and reception time, and calculating delay amount for reception transducer element based on total propagation time; delay processor specifying reception signal value corresponding to delay amount, from reception signal sequence corresponding to reception transducer element; and adder generating acoustic line signal for measurement point based on specified reception signal value.