WANG DONG,KOPECEK JINDRICH,MILLER SCOTT C.,KOPECKOVÁ PAVLA
申请号:
PL05732710
公开号:
PL1737428T3
申请日:
2005.03.30
申请国别(地区):
PL
年份:
2018
代理人:
摘要:
This invention relates to biotechnology, more particularly, to water-soluble polymeric delivery systems for the imaging, evaluation and/or treatment of rheumatoid arthritis and other inflammatory diseases. Using modern MR imaging techniques, the specific accumulation of macromolecules in arthritic joints in adjuvant-induced arthritis in rats is demonstrated. The strong correlation between the uptake and retention of the MR contrast agent labeled polymer with histopathological features of inflammation and local tissue damage demonstrates the practical applications of the macromolecular delivery system of the invention.