THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES
发明人:
CHINNASAMY, Dhanalakshmi,WHITEHILL, Gregory, D.,BARRETT, Austin, J.
申请号：
WO2016US29333
公开号：
WO2016176193(A1)
申请日:
2016.04.26
申请国别(地区):
世界知识产权组织国际局
年份:
2016
代理人:
摘要：
Disclosed herein is a method to specifically remove alloreactive T cells. In one example, the method includes culturing donor cells comprising donor T cells with recipient antigen presenting cells (APCs) to form a mixture of cells under conditions sufficient for recipient APCs to activate donor T cells; contacting the mixture of cells with an effective concentration of adenosine or adenosine-like molecule to decrease or inhibit viability of the activated donor T-cells; and removing the adenosine or adenosine-like molecule from the mixture of cells. The resulting cells can be given to the recipient. This method can be used to prevent, reduce or inhibit graft-versus-host disease (GVHD).
