In an embodiment the instant invention discloses a modular composition comprising 1) an oligonucleotide； 2) one or more linkers, which may be the same or different, selected from Table 1, wherein the linkers are attached to the oligonucleotide at the 2'-position of the ribose rings and/or the terminal 3'- and/or 5'-positions of the oligonucleotide； 3) optionally, one or more peptides, which may be the same or different, selected from SEQ ID NOs: 1-59, wherein the peptides are attached to the linkers； and optionally one or more lipids, solubilizing groups and/or targeting ligands attached to the oligonucleotide.
