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NOVEL SINGLE CHEMICAL ENTITIES AND METHODS FOR DELIVERY OF OLIGONUCLEOTIDES
专利权人:
SIRNA THERAPEUTICS; INC.
发明人:
AARONSON, JEFFREY, G.,BARNETT, STANLEY, F.,BARTZ, RENE,COLLETTI, STEVEN, L.,JADHAV, VASANT, R.,MOMOSE, AARON, A.,SHAW, ANTHONY, W.,TELLERS, DAVID, M.,TUCKER, THOMAS, J.,WANG, WEIMIN,YUAN, YU
申请号:
EP11766550
公开号:
EP2555777A4
申请日:
2011.04.04
申请国别(地区):
EP
年份:
2015
代理人:
摘要:
In an embodiment the instant invention discloses a modular composition comprising 1) an oligonucleotide 2) one or more linkers, which may be the same or different, selected from Table 1, wherein the linkers are attached to the oligonucleotide at any 3&prime and/or 5&prime end 3) one or more peptides, which may be the same or different, selected from SEQ ID NOs: 1-59, wherein the peptides are attached to the linkers and optionally one or more lipids, solubilizing groups and/or targeting ligands attached to the oligonucleotide.
来源网站:
中国工程科技知识中心
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http://www.ckcest.cn/home/

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