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NOVEL SINGLE CHEMICAL ENTITIES AND METHODS FOR DELIVERY OF OLIGONUCLEOTIDES
专利权人:
发明人:
AARONSON JEFFREY G,BARNETT STANLEY F,BARTZ RENE,COLLETTI STEVEN L,JADHAV VASANT R,MOMOSE AARON A,SHAW ANTHONY W,TELLERS DAVID M,TUCKER THOMAS J,WANG WEIMIN,YUAN YU
申请号:
IN7330/CHENP/2012
公开号:
IN2012CN07330A
申请日:
2012.08.23
申请国别(地区):
IN
年份:
2013
代理人:
摘要:
In an embodiment the instant invention discloses a modular composition comprising 1) an oligonucleotide 2) one or more linkers which may be the same or different selected from Table 1 wherein the linkers are attached to the oligonucleotide at any 3 and/or 5 end 3) one or more peptides which may be the same or different selected from SEQ ID NOs: 1 59 wherein the peptides are attached to the linkers and optionally one or more lipids solubilizing groups and/or targeting ligands attached to the oligonucleotide.
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