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CYCLIC AMINE DERIVATIVES AS EP4 RECEPTOR ANTAGONISTS
专利权人:
РОТТАФАРМ БИОТЕК С.Р.Л. (IT)
发明人:
БОРРЬЕЛЛО Мануэла (IT),ПУЧЧИ Сабрина (IT),СТАЗИ Луиджи Пьеро (IT),РОВАТИ Лучио (IT)
申请号:
RU2014103587/04
公开号:
RU2014103587A
申请日:
2011.07.04
申请国别(地区):
RU
年份:
2015
代理人:
摘要:
1. The cyclic amine compound of formula (I): or a pharmaceutically acceptable salt or derivative thereof, wherein: A is selected from the group consisting of n = 0, 1 or 2, m = 0 or 1, R and R are independently hydrogen, linear or branched C1-6 alkyl or are combined with each other to form a cyclopropyl ring; R is H or a linear or branched C1-6 alkyl; R and R are independently hydrogen, fluoro, linear or branched C1-6 alkyl or combined with each other to form a cyclopropyl ring, Ar is phenyl, soda holding: i. at position 4, one substituent selected from the group consisting of halogen, cyano, trifluoromethyl, or ii. at position 3, one substituent selected from the group consisting of halogen, cyano, trifluoromethyl, with the proviso that ii.a. if A is B, then both R and R are fluorine, linear or branched C1-6 alkyl or are combined together to form a cyclopropyl ring, ii.b. if A is C, then m is 0, ii.c. if A represents D, then m is 1, a 5-membered heteroaromatic ring containing from 1 to 3 heteroatoms, where said heteroatoms are independently S, O or N; or a 6-membered heteroaromatic ring containing from 1 to 3 N.2 atoms. A cyclic amine compound of the formula (I) according to claim 1, wherein Ar is phenyl containing at the 4 position one substituent selected from fluoro, cyano or trifluoromethyl. 3. A cyclic amine compound of the formula (I) according to claim 2, wherein R 1 is hydrogen, and R 1 is methyl, or R 1 and R 2 are connected together to form a cyclopropyl ring. The cyclic amine compound according to claim 1, where A is B, have1. Соединение циклического амина формулы (I):или его фармацевтически приемлемая соль или производное, где:А выбрано из группы, состоящей изгдеn=0, 1 или 2,m=0 или 1,Rи Rнезависимо представляют собой водород, линейный или разветвленный Cалкил или объединены друг с другом с образованием циклопропильного кольца;Rпредставляет собой H или линейный или разветвленный Cалкил;Rи Rнезависимо представляют собой водород, фтор, линейный или развет
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