A multi-layer particle structure containing extract of Psidium guajava Linn., guava for regulating blood glucose, wherein the particle structure comprises at least: a core body which comprises extract of guava; and a structure layer which is wrapped on the outside of the core body.一種調節血糖之含芭樂(Psidium guajava Linn.,guava)萃取物的多層微粒結構,其中,該微粒結構由內而外至少包含:一核心體,其係包含芭樂萃取物;以及一結構層,其係包覆於該核心體的外側。