WILLIAMS, BRIAN JOHN,BERDINI, VALERIO,CARR, MARIA GRAZIA,CONGREVE, MILES STUART,FREDERICKSON, MARTYN,GRIFFITHS-JONES, CHARLOTTE MARY,HAMLETT, CHRISTOPHER CHARLES FREDERICK,MADIN, ANDREW,MURRAY, CHRIST
申请号：
NZ58978109
公开号：
NZ589781A
申请日:
2009.06.12
申请国别(地区):
NZ
年份:
2013
代理人:
摘要：
589781 Disclosed herein are imidazo[1,2-a]pyridinyl containing urea compounds and the use thereof in the treatment of a disease mediated by FGFR kinase, such as cancer. Exemplary compounds include: 1-(3-{ 7-[5-(tetrahydrofuran-2-yl)-[1,3,4]thiadiazol-2-yl]imidazo[1,2-a]pyridin-3-yl} -phenyl)-3-(2,2,2-trifluoroethyl)urea, 1-[3-(7-pyridazin-3-ylimidazo[1,2-a]pyridin-3-yl)phenyl]-3-(2,2,2-trifluoroethyl)urea hydrochloride, N-methyl-2-[4-(3-{ 3-[3-(2,2,2-trifluoro-ethyl)-ureido]-phenyl} -imidazo[1,2-a]pyridin-7-yl)-pyrazol-1-yl]-isobutyramide, and 1-ethyl-3-{ 3-[7-(5-fluoro-6-methyl-pyridin-2-yl)-imidazo[1,2-a]pyridin-3-yl]-phenyl} -urea.
