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Crystalline (r)-(e)-2-(4-(2-(5-(1-(3,5-dichloropyridin-4-yl)ethoxy)-1h-indazol-3-yl)vinyl)-1h-pyrazol-1-yl)ethanol and its use as fgfr inhibitor
专利权人:
ELI LILLY AND COMPANY
发明人:
Diseroad Benjamin Alan
申请号:
NZ60848211
公开号:
NZ608482A
申请日:
2011.09.29
申请国别(地区):
NZ
年份:
2014
代理人:
摘要:
608482 Provided are crystalline forms of (R)-(E)-2-(4-(2-(5-(1-(3,5-dichloropyridin-4-yl)ethoxy)-1H-indazol-3-yl)vinyl)-1H-pyrazol-1-yl) ethanol. A preferred crystalline form is (R)-(E)-2-(4-(2-(5-(1-(3,5-dichloropyridin-4-yl)ethoxy)-1H-indazol-3-yl)vinyl)-1H-pyrazol-1-yl) ethanol monohydrate. A crystalline form can be characterised by the X-ray powder diffraction pattern (Cu radiation, λ = 1.54059 Å) comprising a peak at 14.65 (20+/-0.1°) and comprising further peaks at 3.54 (20+/-0.1°), 12.51 (20+/-0.1°) and 19.16 (20+/-0.1°). The crystalline forms can be used in the treatment of cancer. Further provided is a pharmaceutical composition comprising the crystalline forms.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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