BRUCE IAN,CHAMOIN SYLVIE,COLLINGWOOD STEPHEN PAUL,FURET PASCAL,FURMINGER VIKKI,LEWIS SARAH,LOREN JON CHRISTOPHER,MOLTENI VALENTINA,SAUNDERS ALEX MICHAEL,SHAW DUNCAN,SVIRIDENKO LILYA,THOMSON CHRISTOPHE
申请号：
NZ62143612
公开号：
NZ621436A
申请日:
2012.08.31
申请国别(地区):
NZ
年份:
2015
代理人:
摘要：
Provided are imidazopyridine and pyrazolopyridine derivative compounds of the general formula (I), wherein the variables are as defined in the specification. Examples of the compounds include N-(2-Fluoro-5-(2-(4-methylpiperazin-1-yl)benzylcarbamoyl)phenyl)-7-(1-methyl-1H-pyrazol-5-yl)imidazo[1,2-a]pyridine-3-carboxamide and N-(5-((2-(2,2-dimethylpyrrolidin-1-yl)ethyl)carbamoyl)-2-methylpyridin-3-yl)-6-( 1-methyl-1H-pyrazol-5-yl)pyrazolo[1,5-a]pyridine-3-carboxamide. The compounds are inhibitors of PDGFR kinase. The compounds may be useful in the treatment of pulmonary arterial hypertension.
