FORMAS CRISTALINAS DE 3-(2, 6-DICLORO-3, 5-DIMETOXI-FENIL)-1-{6-4[4-(4-ETIL-PIPERAZIN-1-IL)-FENIL-AMINO]-PIRIMIDIN-4-IL}-1-METIL-UREA Y SALES DE LAS MISMAS
BERGHAUSEN, JOERG,KAPA, PRASAD KOTESWARA,MCKENNA, JOSEPH,SLADE, JOEL,WU, RAEANN,DU, ZHENGMING,STOWASSER, FRANK
申请号：
PE0007722012
公开号：
PE14992012A1
申请日:
2010.12.06
申请国别(地区):
PE
年份:
2012
代理人:
摘要：
Refers to a compound of formula (i) where: (a) The anhydrous Crystalline form shows a diffraction Pattern in x-ray Powder comprising one or more peaks at 2 Theta terms selected from peaks at approximately 12, 10.5\u00ba, 15.2\u00ba, 19.5\u00ba and 21.Package (b) the manner of Monohydrate Crystal shows a diffraction Pattern in x-ray Powder comprising one or more peaks at 2 Theta terms selected from peaks at approximately 20.3\u00ba, 21.3\u00ba, 18.8\u00ba, 4.7\u00ba, 9.4\u00ba and 11.Package (c) The Crystalline Salt anhydrous acid monofosforico shows a diffraction Pattern in x-ray Powder comprising one or more peaks at 2 Theta terms selected from peaks at approximately: Fifteenth, 13.7\u00ba, 16.8\u00ba, 21.3\u00ba, 22.4\u00ba, 9.2\u00ba, 9.6\u00ba, 18.7\u00ba, 20.0\u00ba, 22.9\u00ba and 27.2 (d) The hydrochloride Salt shows a diffraction Pattern in x-ray Powder comprising one or more peaks at 2 Theta terms selected from peaks at approximately 10.9\u00ba, 12.1\u00ba, 14.8\u00ba, 20.5\u00ba, Twenty second and 25.1\u00ba. It also relates to a Pharmaceutical composition. This Compound is an inhibitor of kinase FGFR1, FGFR2, FGFR3, fgfr4, kdr, HER1, HER2, bcr abl, Tie2 and ret.To be useful for the treatment of cancerSE REFIERE A UN COMPUESTO DE FORMULA (I) DONDE: A) LA FORMA CRISTALINA ANHIDRA PRESENTA UN PATRON DE DIFRACCION EN POLVO DE RAYOS X QUE COMPRENDE UNO O MAS PICOS EN TERMINOS 2 THETA SELECCIONADOS A PARTIR DE PICOS A APROXIMADAMENTE 12º, 10.5º, 15.2º, 19.5º Y 21.0º (B) LA FORMA DE MONOHIDRATO CRISTALINO PRESENTA UN PATRON DE DIFRACCION EN POLVO DE RAYOS X QUE COMPRENDE UNO O MAS PICOS EN TERMINOS 2 THETA SELECCIONADOS A PARTIR DE PICOS A APROXIMADAMENTE 20.3º, 21.3º, 18.8º, 4.7º, 9.4º Y 11.0º (C) LA SAL CRISTALINA ANHIDRA DEL ACIDO MONOFOSFORICO PRESENTA UN PATRON DE DIFRACCION EN POLVO DE RAYOS X QUE COMPRENDE UNO O MAS PICOS EN TERMINOS 2 THETA SELECCIONADOS A PARTIR DE PICOS A APROXIMADAMENTE: 15º, 13.7º, 16.8º, 21.3º, 22.4º, 9.2º, 9.6º, 18.7º, 20.0º, 22.9º
