The invention refers to an antibody added with a hardening region, which includes amino 86-111 SEQ ID No.1, characterized in that it contains one or more substitutes in each of the following fields: the first domain CH3, the second domain CH3, One ch1 domain and one CL domain. Among these or more alternatives, one or more wildlife IgG positive and negative charges (such as Lys, his and Arg) are replaced by one or more loads (such as ASP and Glu),Or, one or more negative loaded amino acids of wild animals can be replaced by one or more positive and negative charges, so as to promote the formation of heterosexuals in electronics, but not the formation of homosexuals. It also refers to the heterosclerotic antigen, including the first heavy chain and the first light chain, which contain a piece of fragment bonded to the hardening, the second heavy chain and the second heavy chain, which include a piece of fragment bonded to DKK-1. This antibody is an effective way to treat disorders related to low Ossetian mineral density.La invencion se refiere a anticuerpos que se unen a una region de esclerostina que comprende los aminoacidos 86-111 de SEQ ID NO: 1, caracterizados porque comprenden una o mas sustituciones en cada uno de los siguientes dominios: un primer dominio CH3, un segundo dominio CH3, un dominio CH1 y un dominio CL. En dichas una o mas sustituciones se reemplazan uno o mas aminoacidos de carga positiva en la IgG de tipo silvestre (por ejemplo, Lys, His y Arg) por uno o mas de carga negativa (por ejemplo, Asp y Glu), y alternativamente se reemplazan uno o mas aminoacidos de carga negativa en la IgG de tipo silvestre por una o mas de carga positiva, a fin de favorecer electrostaticamente la formacion de heterodimeros y desfavoreciendo la formacion de homodimeros. Tambien se refiere a anticuerpos anti-esclerostina heterodimericos que comprenden una primera cadena pesada y una primera cadena liviana comprendiendo un fragmento de union a esclerostina, y una segunda
