BERGHAUSEN, JOERG,KAPA, PRASAD KOTESWARA,MCKENNA, JOSEPH,SLADE, JOEL,WU, RAEANN,DU, ZHENGMING,STOWASSER, FRANK
申请号：
PE2012000772
公开号：
PE20121499A1
申请日:
2010.12.06
申请国别(地区):
PE
年份:
2012
代理人:
摘要：
It refers to a formula compound (I), wherein: (a) the dihydrocrystalline form contains an X-ray powder derivative consisting of one or more termite peaks, selected from the peaks to about 12 topics.10.5,15.2%Sections 19.5 and 21.0(b) the shape of the crystal hydrate is X-ray powder diffraction, including one or more peaks of termites and two themes, ranging from the peak to about 20.3 degrees,21.3.18.8 degrees4.7 degreesSections 9.4 and 11.0(c) the crystal free salt of calcium monophosphate has the diffraction characteristics of an X-ray powder, which includes two themes of one or more termite peaks, from the peak to about: 15,13.7 degrees16.8 degrees21.3.22.4%9.2.9.6%18.7 degrees20 degreesSections 22.9 and 27.2(d) the hydrochloride has an X-ray powder diffraction device, which includes one or more termite peaks 2 theta, ranging from the peak to about 10.9 degrees；Twelve point one14.8 degrees20.5 degreesPage: 1 He also mentioned a composer of pharmacology The compound is a kind of substance which can inhibit cinasa FGFR1, FGFR2, FGFR3, FGFR4, KDR, HER1, HER2, bcr-abl, Tie2 and ret.SE REFIERE A UN COMPUESTO DE FORMULA (I) DONDE: A) LA FORMA CRISTALINA ANHIDRA PRESENTA UN PATRON DE DIFRACCION EN POLVO DE RAYOS X QUE COMPRENDE UNO O MAS PICOS EN TERMINOS 2 THETA SELECCIONADOS A PARTIR DE PICOS A APROXIMADAMENTE 12º, 10.5º, 15.2º, 19.5º Y 21.0º； (B) LA FORMA DE MONOHIDRATO CRISTALINO PRESENTA UN PATRON DE DIFRACCION EN POLVO DE RAYOS X QUE COMPRENDE UNO O MAS PICOS EN TERMINOS 2 THETA SELECCIONADOS A PARTIR DE PICOS A APROXIMADAMENTE 20.3º, 21.3º, 18.8º, 4.7º, 9.4º Y 11.0º； (C) LA SAL CRISTALINA ANHIDRA DEL ACIDO MONOFOSFORICO PRESENTA UN PATRON DE DIFRACCION EN POLVO DE RAYOS X QUE COMPRENDE UNO O MAS PICOS EN TERMINOS 2 THETA SELECCIONADOS A PARTIR DE PICOS A APROXIMADAMENTE: 15º, 13.7º, 16.8º, 21.3º, 22.4º, 9.2º, 9.6º, 18.7º, 20.0º, 22.9º Y 27.2º； D) LA SAL DE CLORHIDRATO PRESENTA UN PATRON DE DIFRACCION EN POLVO DE RAYOS X QUE COMPRENDE UNO O MAS PICOS EN TERMINOS 2
