Christin, Brian,Covington, Michael Gerard,Dave, Kedar Himanshu,Getto Jr., Richard James,Kowski, Tom,Larson, Ryan P.,Ramsborg, Christopher Glen,Trede, Nikolaus Sebastian,Weber, Clinton,Whitmore, James
申请号：
AU2018224856
公开号：
AU2018224856A1
申请日:
2018.02.27
申请国别(地区):
AU
年份:
2019
代理人:
摘要：
Provided herein are methods, compositions and articles of manufacture for use in connection with cell therapy involving the administration of one or more doses of a therapeutic T cell composition. The cells of the T cell composition express recombinant receptors such as chimeric receptors, e.g. chimeric antigen receptors (CARs) or other transgenic receptors such as T cell receptors (TCRs). Features of the provided embodiments, including the numbers of cells or units of cells administered and/or the potency of administered cells, provide various advantages, such as lower risk of toxicity in subjects administered the T cell compositions.
