Brian CHRISTIN,Michael Gerard COVINGTON,Kedar Himanshu DAVE,Richard James GETTO, Jr.,Tom KOWSKI,Ryan P. LARSON,Christopher Glen RAMSBORG,Nikolaus Sebastian TREDE,Clinton WEBER,James Boyd WHITMORE,Nath
申请号：
US16488935
公开号：
US20200191774A1
申请日:
2018.02.27
申请国别(地区):
US
年份:
2020
代理人:
摘要：
Provided herein are methods, compositions and articles of manufacture for use in connection with cell therapy involving the administration of one or more doses of a therapeutic T cell composition. The cells of the T cell composition express recombinant receptors such as chimeric receptors, e.g. chimeric antigen receptors (CARs) or other transgenic receptors such as T cell receptors (TCRs). Features of the provided embodiments, including the numbers of cells or units of cells administered and/or the potency of administered cells, provide various advantages, such as lower risk of toxicity in subjects administered the T cell compositions.
