CHRISTIN, BRIAN,DAVE, KEDAR HIMANSHU,GETTO, RICHARD JAMES, JR.,KOWSKI, TOM,LARSON, RYAN P.,RAMSBORG, CHRISTOPHER GLEN,TREDE, NIKOLAUS SEBASTIAN,WEBER, CLINTON,WHITMORE, JAMES BOYD,YEE, NATHAN,BEAUCHES
申请号：
CA3053539
公开号：
CA3053539A1
申请日:
2018.02.27
申请国别(地区):
CA
年份:
2018
代理人:
摘要：
Provided herein are methods, compositions and articles of manufacture for use in connection with cell therapy involving the administration of one or more doses of a therapeutic T cell composition. The cells of the T cell composition express recombinant receptors such as chimeric receptors, e.g. chimeric antigen receptors (CARs) or other transgenic receptors such as T cell receptors (TCRs). Features of the provided embodiments, including the numbers of cells or units of cells administered and/or the potency of administered cells, provide various advantages, such as lower risk of toxicity in subjects administered the T cell compositions.
