Cryotherapeutic systems and cryotherapeutic-system components configured for renal neuromodulation are disclosed herein. A cryotherapeutic system configured in accordance with a particular embodiment of the present technology can include a console having a cartridge housing, a cartridge connector adjacent to the cartridge housing, and a supply passage fluidly connected to the cartridge connector. The console can further include a supply valve along the supply passage and a control assembly including a supply-valve actuator and a user interface. The supply-valve actuator can be operably connected to the supply valve, and the control assembly can be configured to signal the supply-valve actuator to open the supply valve in response to a signal from the user interface.
