THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK;PINSKY, DAVID, J.
发明人:
PINSKY, DAVID, J.
申请号：
WO2000US22060
公开号：
WO0111949(A1)
申请日:
2000.08.11
申请国别(地区):
世界知识产权组织国际局
年份:
2001
代理人:
摘要：
The present invention provides a method of treating or preventing thrombotic or ischemic disorders in a subject which comprises administering an agent to the subject, wherein the agent inhibits ADP-mediated platelet aggregation by increasing ADP catabolism, and a method for determining whether a compound inhibits platelet aggregation by increasing ADP catabolism so as to treat or prevent thrombotic or ischemic disorders in a subject, comprising: a) inducing thrombotic or ischemic disorders in an animal, which animal is an animal model for thrombotic or ischemic disorders; b) measuring the stroke outcome in said animal; c) measuring platelet deposition and/or fibrin deposition in ischemic tissue; and d) comparing the stroke outcome in step (b) and the platelet deposition and/or fibrin deposition with that of the animal model in the absence of the compound so as to identify a compound capable of treating or preventing thrombotic or ischemic disorders in a subject.
