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Bacterially derived intact minicells that encompass plasmid free functional nucleic acid for in vivo delivery to mammalian cells
专利权人:
Himanshu Brahmbhatt;Jennifer MacDiarmid;Toby Hulf
发明人:
Himanshu Brahmbhatt,Jennifer MacDiarmid,Toby Hulf
申请号:
US12980781
公开号:
US08669101B2
申请日:
2010.12.29
申请国别(地区):
US
年份:
2014
代理人:
摘要:
Intact, bacterially-derived minicells can safely introduce therapeutically effective amounts of plasmid-free functional nucleic acid to target mammalian cells. To this end, functional nucleic acid can be packaged into intact minicells directly, without resort to expression constructs, the expression machinery of the host cell, harsh chemicals or electroporation.
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