Bacterially derived intact minicells that encompass plasmid free functional nucleic acid for in vivo delivery to mammalian cells

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专利权人:

Himanshu Brahmbhatt

发明人:

Himanshu Brahmbhatt,Jennifer MacDiarmid,Toby Hulf

申请号：

US12053197

公开号：

US08735566B2

申请日:

2008.03.21

申请国别(地区):

US

年份:

2014

代理人:

摘要：

Intact, bacterially-derived minicells can safely introduce therapeutically effective amounts of plasmid-free functional nucleic acid to target mammalian cells. To this end, functional nucleic acid can be packaged into intact minicells directly, without resort to expression constructs, the expression machinery of the host cell, harsh chemicals or electroporation.

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