Shouchun Chen,Qi Xu,Juan Yan,Xianzhou Huang,Lijia Wei,Haiyang Hu
申请号：
US15892438
公开号：
US20180170994A1
申请日:
2018.02.09
申请国别(地区):
US
年份:
2018
代理人:
摘要：
The present invention belongs to the field of genetic engineering drugs, and provides a mutein MuR5S4TR of TRAIL, and a preparation method and use thereof. The N-terminal positions 2-10 of the amino acid sequence of the mutein consist of the transmembrane peptide sequence RRRRR (R5) and the binding sequence AVPI of the apoptosis inhibitor XIAP, the positions 11-169 are the TRAIL protein peptide segment (123-281 aa), and the specific sequence is as shown in SEQ ID NO: 2.
