DOUBLE-TARGET MUTEIN MUR5S4TR OF TRAIL, AND PREPARATION METHOD AND USE THEREOF

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专利权人:

Chengdu Huachuang Biotechnology Co.; Ltd

发明人:

CHEN, Shouchun,XU, Qi,YAN, Juan,HUANG, Xianzhou,WEI, Lijia,HU, Haiyang

申请号：

EP15906480

公开号：

EP3348577A1

申请日:

2015.10.22

申请国别(地区):

EP

年份:

2018

代理人:

摘要：

The present invention belongs to the field of genetic engineering drugs, and provides a mutein MuR5S4TR of TRAIL, and a preparation method and use thereof. The N-terminal positions 2-10 of the amino acid sequence of the mutein consist of the transmembrane peptide sequence RRRRR (R5) and the binding sequence AVPI of the apoptosis inhibitor XIAP, the positions 11-169 are the TRAIL protein peptide segment (123-281 aa), and the specific sequence is as shown in SEQ ID NO: 2.

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