TRAIL Pharmaceutical composition for preventing or treating glioblastoma comprising oleanolic acid derivatives and TNF-related apoptosis inducing ligand as effective component
The present invention relates to a pharmaceutical composition for preventing and treating glioblastoma containing oleanolic acid derivatives and TRAIL as an active ingredient, and more specifically, C27OA-1 to 3, which are oleanolic acid derivatives of the present invention, are TRAIL When treated in parallel with (TNF-related apoptosis inducing ligand), the effect of promoting cell death of glioblastoma, which did not show the anticancer effect by TRAIL anticancer agent or C27OA-1~3, was excellent, and thus oleanolic acid derivative and TRAIL The composition of the present invention containing as an active ingredient can be usefully used as a therapeutic agent for glioblastoma.본 발명은 올레아놀산(oleanolic acid) 유도체 및 TRAIL을 유효성분으로 함유하는 교모세포종 예방 및 치료용 약학 조성물에 관한 것으로, 보다 상세하게는 본 발명의 올레아놀산(oleanolic acid) 유도체인 C27OA-1~3은 TRAIL(TNF-related apoptosis inducing ligand)과 병행 처리하였을 때, TRAIL 항암제 또는 C27OA-1~3에 의한 항암효과가 나타나지 않던 교모세포종의 세포 사멸을 촉진시키는 효과가 우수하였으므로, 올레아놀산(oleanolic acid) 유도체 및 TRAIL을 유효성분으로 함유하는 본 발명의 조성물은 교모세포종의 치료제로 유용하게 사용될 수 있다.
