MACDONALD, Lynn,MURPHY, Andrew J.,TU, Naxin,GURER, Cagan,VORONINA, Vera,STEVENS, Sean
申请号：
ES17171524
公开号：
ES2774488T3
申请日:
2012.10.26
申请国别(地区):
ES
年份:
2020
代理人:
摘要：
The invention provides genetically modified non-human animals that express a humanized MHC II protein (humanized MHC II ± and ² polypeptides), as well as embryos, cells, and tissues comprising the same. Also provided are constructs for making said genetically modified animals and methods of making the same. Methods of using the genetically modified animals to study various aspects of human immune system are provided.
