Lynn MACDONALD,Andrew J. MURPHY,Naxin TU,Cagan GURER,Vera VORONINA,Sean STEVENS
申请号：
US14691175
公开号：
US20150245598A1
申请日:
2015.04.20
申请国别(地区):
US
年份:
2015
代理人:
摘要：
The invention provides genetically modified non-human animals that express a humanized MHC II protein (humanized MHC II α and β polypeptides), as well as embryos, cells, and tissues comprising the same. Also provided are constructs for making said genetically modified animals and methods of making the same. Methods of using the genetically modified animals to study various aspects of human immune system are provided.
