#$%^&*AU2018203261A120180531.pdf#####ABSTRACT Antibodies or antigen-binding fragments thereof are engineered to bind Transforming Growth Factor-3 (TGF3). TGF-isoform selective antibodies or antigen-binding fragments thereof may selectively bind human TGFP 1, compared to human TGF32 and human TGF33, 5 or may selectively bind human TGFP3, compared to human TGFP 1 and human TGF32. The design of the antibodies or antigen-binding fragments thereof is facilitated by a co-crystal structure of a recombinant Fab fragment of GC1008 bound to TGF32 and by another cocrystal structure of the scFv version of GC 1008 bound to TGFP 1.
