ENGINEERED ANTI-TGF-BETA ANTIBODIES AND ANTIGEN-BINDING FRAGMENTS

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专利权人:

GENZYME CORPORATION

发明人:

WEI, RONNIE,MOULIN, AARON,MATHIEU, MAGALI,PAN, CLARK,PARK, SUNGHAE,QIU, HUAWEI

申请号：

SG11201507279X

公开号：

SG11201507279XA

申请日:

2014.03.11

申请国别(地区):

SG

年份:

2015

代理人:

摘要：

Antibodies or antigen-binding fragments thereof are engineered to bind Transforming Growth Factor-² (TGF²). TGF²-isoform selective antibodies or antigen-binding fragments thereof may selectively bind human TGF²1 compared to human TGF²2 and human TGF²3, or may selectively bind human TGF²3, compared to human TGF²1 and human TGF²2. The design of the antibodies or antigen-binding fragments thereof is facilitated by a co-crystal structure of a recombinant Fab fragment of GC1008 bound to TGF²2 and by another co-crystal structure of the scFv version of GC1008 bound to TGF²1.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/