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ENGINEERED ANTI-TGF-BETA ANTIBODIES AND ANTIGEN-BINDING FRAGMENTS
专利权人:
GENZYME CORPORATION
发明人:
WEI, RONNIE,MOULIN, AARON,MATHIEU, MAGALI,PAN, CLARK,PARK, SUNGHAE,QIU, HUAWEI
申请号:
SG11201507279X
公开号:
SG11201507279XA
申请日:
2014.03.11
申请国别(地区):
SG
年份:
2015
代理人:
摘要:
Antibodies or antigen-binding fragments thereof are engineered to bind Transforming Growth Factor-² (TGF²). TGF²-isoform selective antibodies or antigen-binding fragments thereof may selectively bind human TGF²1 compared to human TGF²2 and human TGF²3, or may selectively bind human TGF²3, compared to human TGF²1 and human TGF²2. The design of the antibodies or antigen-binding fragments thereof is facilitated by a co-crystal structure of a recombinant Fab fragment of GC1008 bound to TGF²2 and by another co-crystal structure of the scFv version of GC1008 bound to TGF²1.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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