Engineered anti-TGF-beta antibodies and antigen-binding fragments

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专利权人:

Genzyme Corporation

发明人:

Wei, Ronnie,Moulin, Aaron,Mathieu, Magali,Pan, Clark,Park, Sunghae,Qiu, Huawei

申请号：

AU2014249051

公开号：

AU2014249051A1

申请日:

2014.03.11

申请国别(地区):

AU

年份:

2015

代理人:

摘要：

Antibodies or antigen-binding fragments thereof are engineered to bind Transforming Growth Factor-β (TGFβ). TGFβ-isoform selective antibodies or antigen-binding fragments thereof may selectively bind human TGFβ1, compared to human TGFβ2 and human TGFβ3, or may selectively bind human TGFβ3, compared to human TGFβ1 and human TGFβ2. The design of the antibodies or antigen-binding fragments thereof is facilitated by a co-crystal structure of a recombinant Fab fragment of GC1008 bound to TGFβ2 and by another co-crystal structure of the scFv version of GC1008 bound to TGFβ1.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/