CORCORAN, JONATHAN PATRICK THOMAS,KALINDJIAN, SARKIS BARRET,BORTHWICK, ALAN DAVID,ADAMS, DAVID REGINALD,BROWN, JANE THERESA,TADDEI, DAVID MICHEL ADRIEN,SHIERS, JASON, JOHN
申请号：
SG2012011193
公开号：
SG178480A1
申请日:
2010.09.01
申请国别(地区):
SG
年份:
2012
代理人:
摘要：
The present invention pertains generally to the field of therapeutic compounds, and more specifically to certain aryl-amido-aryl compounds of the following formula (for convenience, collectively referred to herein as "AAA compounds"), which, inter alia, are (selective) retinoic acid receptor α (RARα) agonists. The present invention also pertains to pharmaceutical compositions comprising such compounds, and the use of such compounds and compositions, both in vitro and in vivo, to (selectively) activate RARα, and in the treatment of diseases and conditions that are mediated by RARα, that are ameliorated by the activation of RARα, etc., including cognitive disorders, memory impairment, memory deficit, senile dementia, Alzheimers disease, early stage Alzheimers disease, intermediate stage Alzheimers disease, late stage Alzheimers disease, cognitive impairment, and mild cognitive impairment.
