Jonathan Patrick Thomas Corcoran,Sarkis Barret Kalindjian,Alan David Borthwick,David Reginald Adams,Jane Theresa Brown,David Michel Adrien Taddei,Jason John Shiers
申请号：
US14879340
公开号：
US09447028B2
申请日:
2015.10.09
申请国别(地区):
US
年份:
2016
代理人:
摘要：
The present invention pertains generally to the field of therapeutic compounds, and more specifically to certain aryl-amido-aryl compounds of the following formula (for convenience, collectively referred to herein as “AAA compounds”), which, inter alia, are (selective) retinoic acid receptor α (RARα) agonists. The present invention also pertains to pharmaceutical compositions comprising such compounds, and the use of such compounds and compositions, both in vitro and in vivo, to (selectively) activate RARα, and in the treatment of diseases and conditions that are mediated by RARα, that are ameliorated by the activation of RARα, etc., including cognitive disorders, memory impairment, memory deficit, senile dementia, Alzheimers disease, early stage Alzheimers disease, intermediate stage Alzheimers disease, late stage Alzheimers disease, cognitive impairment, and mild cognitive impairment.
