Corcoran, Jonathan Patrick Thomas,Kalindjian, Sarkis Barret,Borthwick, Alan David,Adams, David Reginald,Brown, Jane Theresa,Taddei, David Michel Adrien,Shiers, Jason John
申请号：
AU2010291056
公开号：
AU2010291056B2
申请日:
2010.09.01
申请国别(地区):
AU
年份:
2016
代理人:
摘要：
The present invention pertains generally to the field of therapeutic compounds, and more specifically to certain aryl-amido-aryl compounds of the following formula (for convenience, collectively referred to herein as "AAA compounds"), which, inter alia, are (selective) retinoic acid receptor α (RARα) agonists. The present invention also pertains to pharmaceutical compositions comprising such compounds, and the use of such compounds and compositions, both in vitro and in vivo, to (selectively) activate RARα, and in the treatment of diseases and conditions that are mediated by RARα, that are ameliorated by the activation of RARα, etc., including cognitive disorders, memory impairment, memory deficit, senile dementia, Alzheimer's disease, early stage Alzheimer's disease, intermediate stage Alzheimer's disease, late stage Alzheimer's disease, cognitive impairment, and mild cognitive impairment.
