IIKURA, HITOSHI,饭仓仁,飯倉仁,HYOUDOH, IKUMI,兵藤郁美,AOKI, TOSHIHIRO,青木纪裕,青木紀裕,FURUICHI, NORIYUKI,古市纪之,古市紀之,MATSUSHITA, MASAYUKI,松下正行,WATANABE, FUMIO,渡边史郎,渡邊史郎,OZAWA, SAWAKO,小泽佐和子,小澤佐和子,SAKAITANI, MA
申请号：
TW096104586
公开号：
TWI376374B
申请日:
2007.02.08
申请国别(地区):
TW
年份:
2012
代理人:
摘要：
The present invention provides a compound represented by general formula (1) below or a pharmaceutically acceptable salt thereof: wherein: X is selected from heteroaryl etc., Y 1 and Y 2 are selected from -N= etc., Y 3 and Y 4 are selected from -CH= etc., A is selected from sulfamide etc., R 1 is selected from hydrogen etc., and R 2 is selected from C 1-6 alkyl etc. The compound or salt has sufficiently high antitumor activity, and is useful in the treatment of cell proliferative disorders, particularly cancers. The present invention also provides a pharmaceutical composition containing the compound or salt as an active ingredient.【課題】；本發明提供下述式(1)化合物或其藥學容許鹽。；【解決手段】；本發明之化合物或鹽為具有充分高之抗腫瘤活性，作為細胞増殖性疾病，尤其癌之治療藥有用。本發明又提供以上述化合物或鹽為有效成分之醫藥組成物；(1)；〔式中X為選自雜芳基等，Y1及Y2為選自N=等，Y3及Y4為選自CH=等，A為選自磺醯胺基等，R1為選自氫原子等，R2為選自C1-6烷基等〕。
