The present invention relates to a novel serotonin reuptake inhibitor comprising a compound of the following formula (1) or a pharmaceutically acceptable salt thereof, which has 5-HT2C antagonism acting as anti-depression and anti-anxiety, in particular, together with 5-HT2C inverse agonism,wherein R1, R2, R3 and R4 are independently hydrogen, C1-6 alkyl, or other R5 is C4-7 alkyl or-(CR8R9)r-E R6, R7, R8 and R9 are independently hydrogen, fluorine, C1-6 alkyl A is C6-10 aryl, heteroaryl, or other r is 1, 2, 3 or 4 E is C3-8 cycloalkyl, C6-10 aryl, or other L is oxygen, sulfur or-NR10- n is 1, 2 or 3 R10 is hydrogen, C1-6 alkyl, or other and X is hydrogen, halogen, or other.本發明是關於一種含有以下式(1)表示的化合物或其藥學上可容許的鹽的新血清素再吸收抑制劑,係合併有抗憂鬱作用及抗焦慮作用的5-HT2C拮抗作用,特別是5-HT2C逆運作作用。[式中,R1、R2、R3及R4是互相獨立的氫原子、C1-6烷基等,R5是C4-7烷基或-(CR8R9)r-E,R6、R7、R8及R9是互相獨立的氫原子、氟原子或C1-6烷基,A是C6-10芳基或雜芳基等,r是1、2、3或4,E是C3-8環烷基、C6-10芳基等,L是氧原子、硫原子或-NR10-,n是1、2或3,R10是氫原子、C1-6烷基等,X是氫原子、鹵原子等]。
