Weizhong Zhu;Khalid Chakir;Rui Ping Xiao;Irving W. Wainer;Farideh M. Beigi;Darrell R. Abernethy
发明人:
Irving W. Wainer,Weizhong Zhu,Khalid Chakir,Rui Ping Xiao,Darrell R. Abernethy,Farideh M. Beigi
申请号：
US13333866
公开号：
US20120157543A1
申请日:
2011.12.21
申请国别(地区):
US
年份:
2012
代理人:
摘要：
This disclosure concerns the discovery of (R,R)- and (R,S)-fenoterol analogues which are highly effective at binding β2-adrenergic receptors. Exemplary chemical structures for these analogues are provided. Also provided are pharmaceutical compositions including the disclosed (R,R)-fenoterol and fenoterol analogues, and methods of using such compounds and compositions for the treatment of cardiac disorders such as congestive heart failure and pulmonary disorders such as asthma or chronic obstructive pulmonary disease.
