FIELD: medicine, pharmaceutics.SUBSTANCE: invention refers to a compound presented by formula,wherein A1 means benzene or heterocycle specified in a group consisting of pyridine, pyrazine, imidazole, thiazole, pyrimidine, thiophen, pyridazine, benzoxazine and oxobenzoxazine； A2 means benzene, if needed substituted by fluorine, or thiophen； B1 means hydrogen, lower alkyl, if needed substituted by piperazinyl or morpholino, halogen-substituted lower alkyl, lower alkoxy substituted by carbamoyl, acylamino, carbamoyl or lower alkylcarbonyloxy (provided A1 means thiazole, B1 does not mean acylamino)； B2 means hydrogen or a functional group containing at least one nitrogen atom specified in a group consisting of acylamino, pyrrolidinyl, morpholino, piperidinyl, if needed substituted by acyl, piperazinyl, if needed substituted by lower alkyl or acyl, pyrazolyl, diazabicyclo[2.2.1]heptyl, if needed substituted by acyl, and di-(lower alkyl)amino, if needed substituted by amino or acylamino (provided A1 means thiazole, B2 does not mean acylamino)； Y means a group presented by formula,wherein J means ethylene or lower alkynylene； L means a bond； M means a bond； X means -(CH2)m-, -(CH2)m-O- or -(CH2)m-NR2- (wherein m is an integer of 0 to 3, and R2 means hydrogen)； D means -NR3-, wherein R3 means hydrogen； and E means amino, or its pharmaceutically acceptable salt. The compounds of formula (I) are used for preparing a pharmaceutical agent or a pharmaceutical composition for treating or preventing the VAP-1 related diseases.EFFECT: benzene or thiophen derivative as a VAP-1 inhibitor.13 cl, 25 tbl, 125 exИзобретение относится к соединению, представленное формулой (I), в которой A1 обозначает бензол или гетероцикл, выбранный из группы, состоящей из пиридина, пиразина, имидазола, тиазола, пиримидина, тиофена, пиридазина, бензоксазина и оксобензоксазина； A2 обозначает бензол, в случае необходимости замещенный фтором, или тиофен； B1 обозначает водород, низший алкил, в случае необхо
